Transcriptomics of independent CRISPR-edited cell lines reveal ciliary-specific ARL13B dependent changes
Primary cilia coordinate signaling pathways that regulate tissue homeostasis and development, and defects in cilia contribute to numerous ciliopathies. However, the transcriptional consequences of disrupting ciliary protein localization remain poorly defined. ARL13B is a cilia-enriched regulatory GTPase required for ciliary trafficking and signaling. The ARL13BV358A variant is undetectable in…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
