Systematic assessment of transcriptomic and phenotypic biologicalprofiling for mechanism-based hazard assessment using target-annotated reference chemicals in renal proximal tubular epithelialcells
Integrating high-throughput in vitro data into next-generation risk assessment (NGRA) workflows requires screening strategies that yield quantitative potency estimates and mechanistically interpretable biological signals. Transcriptomic and morphological profiling are increasingly adopted for early-stage hazard identification by enabling triage of substances for resource-intensive follow-up and…
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