Protein design to broadly reprogram engineered T cell function
The efficacy of engineered T cell therapies in solid tumors remains limited by T cell dysfunction, driven by complex processes that cannot be easily manipulated via genetic knockouts or overexpression of individual genes. Protein design can create new biological functions that can rewire these consequential cell fate decisions. Here, we introduce OUTLAST Regulators, designed proteins that…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
