Prevalence of Colorectal Cancer Molecular Profiles Is Not Captured by a Single Age Threshold
Early- and average-onset colorectal cancer (CRC) are separated at age 50, but whether this defines a biological threshold remains unclear. To clarify this, we identified molecular profiles in nine harmonised cBioPortal CRC cohorts (4,609 patients) by fitting Bernoulli mixture models to 31 repair-state, genomic-burden, and gene-alteration features, excluding age, sex, and tumour site, and compared…
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