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Intranasal photobiomodulation as an energy-efficient, largely parameter-insensitive alternative to transcranial photobiomodulation

Background: Photobiomodulation (PBM) is an emerging non-invasive light-based brain stimulation technique that can alter cortical oscillations and is currently being pursued for improving cognition and treating neurological and psychiatric conditions. Nearly all human EEG evidence comes from transcranial PBM (tPBM) applied to the forehead, where light must traverse the scalp and thick skull,…

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