Exposure Duration Shapes the Hepatic Response to GenX: Divergent Acute and Chronic Transcriptomic Profiles Reveal Non-Monotonic Dose Effects and Increased Sensitivity in Human Liver Spheroids
Hexafluoropropylene oxide dimer acid (GenX), a replacement for legacy per and polyfluoroalkyl substances (PFAS), is increasingly detected in the environment, yet its chronic toxicity remains poorly characterized. Current safety assessments rely largely on short term, high dose studies that may not capture the biological consequences of long term, low dose exposure. To address this gap, we…
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