Enhanced early IgG-mediated complement deposition in the development of chronic chikungunya virus disease
Chikungunya virus (CHIKV) is an arthritogenic alphavirus that has spread globally and caused significant outbreaks. While CHIKV disease often resolves following acute infection, individuals can progress to chronic CHIKV disease (CCD) characterized by persistent severe joint pain. Antibodies, especially IgG, help clear CHIKV through neutralization and Fc effector functions. Previous studies have…
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