Engineering Heterotypic Biomolecular Condensates with Synthetic Peptides for Controlled Spatial Organization and Liquid-like Nature
Sequence heterogeneity is a defining feature of cellular biomolecular condensates, yet how competing interaction motifs encode their thermodynamic stability, internal organization, and dynamics remains poorly understood. Here, we systematically tune the hydrophobicity mismatch between intrinsically disordered peptide pairs to establish sequence hydrophobicity as a programmable determinant of…
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