Elevated isoform richness in males largely reflects transcriptional noise rather than proteomic complexity
Alternative splicing (AS) can generate multiple RNA isoforms from a single gene and is thought to contribute to phenotypic divergence, including differences between the sexes. Studies in several organisms have documented sex differences in splicing, however these have been largely reliant on short-read RNA sequencing which requires complex algorithms to assemble full-length transcripts and may…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
