DJ-1/PARK7 Determines miRNA Network Plasticity During Genotoxic Stress
PARK7 (DJ-1) is a redox-sensitive protein that supports cellular adaptation, but its role in post-transcriptional responses to genotoxic stress remains unclear. We investigated whether DJ-1 abundance determines the miRNA response to X-ray-induced DNA damage. Integrated mRNA-seq and small RNA-seq across DJ-1 states in HEK293 cells revealed a striking divergence in miRNA plasticity. DJ-1 depletion…
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