A two-oscillator SCN model with period adaptation and systemic feedback captures photoperiod and T-cycle aftereffects in vivo and in explants
Light history leaves persistent changes in circadian period, but where this history is stored remains unresolved. Suprachiasmatic nucleus (SCN) network models have often approached photoperiodic encoding through phase organization or coupling strength. We computationally tested slow adaptation of subregion-specific intrinsic periods as an alternative memory mechanism. The model asymmetrically…
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