A rationally designed neuraminidase immunogen elicits humoral responses to a conserved viral site
Efforts to develop a universal influenza vaccine have primarily focused on the surface-exposed viral hemagglutinin (HA), but neuraminidase (NA) is an additional target for cross-reactive, protective responses. Here, we used hyperglycosylation as an immunogen design approach to reshape anti-NA humoral immunity toward conserved antigenic regions. Iterative design produced a hyperglycosylated NA…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
