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scDIVA: semi-supervised integration and fine-grained annotation of tumor-immune single-cell atlases

Single-cell atlases of the tumor-immune microenvironment have defined numerous fine-grained immune cell states, but each study uses its own nomenclature and procedure for annotating cell types. Transferring annotations from a reference atlas to a query dataset is complicated by both batch effects and by the presence of query populations that the reference does not contain. Here we present scDIVA,…

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