Review identifies most effective treatments for bipolar disorder
Results from the review have also been used to update guidelines, including those of the International Society for Bipolar Disorders (ISBD), for the management of bipolar disorder
A new review of 77 meta-analyses examining 116 bipolar disorder treatments has identified the most effective interventions across different age groups and mood phases. Bipolar disorder is characterized by extreme mood swings, ranging from depression to mania. Researchers from The Ottawa Hospital in Canada and universities in Europe compiled the EBI-BD (Evidence Based Interventions for Bipolar Disorder) platform, which presents the impact, side effects, and strength of evidence for each treatment based on the most comprehensive review published in The British Medical Journal.
For bipolar depression in adults, effective treatments include cariprazine, fluoxetine, and lurasidone, while children and teenagers responded well to lurasidone, olanzapine, and fluoxetine. Effective interventions for mania episodes in adults include aripiprazole, haloperidol, lithium, and risperidone, while children and teenagers responded best to aripiprazole, asenapine, and olanzapine.
For maintenance doses to prevent future episodes, effective treatments for adults include aripiprazole, lithium, and risperidone. The platform aims to help clinicians find the best balance between efficacy and side effects for each patient. Co-author Michele De Prisco emphasized the importance of shared decision-making between clinicians and patients when selecting treatments.
The authors also updated guidelines from the International Society for Bipolar Disorders, and the review serves as a living resource that can be adapted as new evidence emerges, making it a valuable tool for updating international treatment guidelines.
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