A novel TRPA1 gain-of-function variant associated with painful sensory neuropathy acts through a PIP2 gating mechanism.
TRPA1 (transient receptor potential ankyrin 1) is a non-selective, calcium-permeable cation channel that mediates pain by detecting environmental irritants and thermal stimuli. Although the role of TRPA1 in modulating pain perception is relatively well established, so far only a few human TRPA1 variants (N855S and A172V) have been associated with inherited neuropathic pain disorders. Here, we…
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