Trpv1+ sensory innervation of the salivary gland drives pain and supports saliva secretion
Sensory neurons have been increasingly recognized as vital contributors to deep tissue function. However, how these specialized neurons contribute to salivary gland function remains largely undefined. Here, we uncover a role for trigeminal somatosensory afferents in salivary gland perception and function using in situ-based classification, in vivo calcium imaging, behavioral assays, and targeted…
New research sheds light on the role of sensory nerves in the salivary gland. Sensory neurons, particularly those expressing a protein called TRPV1, have been found to play a crucial role in both the perception and production of saliva. Utilizing sophisticated techniques such as in situ-based classification, in vivo calcium imaging, behavioral tests, and targeted ablation, scientists discovered that these neurons provide extensive direct innervation to the salivary ducts.
When TRPV1-expressing neurons were activated by a TRPV1 agonist, it led to a direct activation of associated neurons in the trigeminal ganglia, resulting in a noticeable pain response. However, when these neurons were selectively eliminated, it caused severe structural damage to the salivary ducts and significantly decreased the volume of saliva produced in response to stimulation.
This groundbreaking study presents the first evidence that TRPV1-positive sensory neurons are essential for maintaining the architecture of the salivary gland and are necessary for the secretion of saliva, highlighting the vital interoceptive role of direct trigeminal innervation in the health of the submandibular gland.
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