Drug-carrying nanoparticles shrink venous malformations by 70% in mice
Venous malformations are abnormally shaped veins that develop when the cells lining blood vessels grow too fast when they aren't supposed to. Children can be born with them, and as the child grows, the venous malformations can get bigger. Venous malformations are a type of vascular malformation that can range from small and superficial to disfiguring, debilitating or even life-threatening.
Venous malformations are abnormal veins that grow rapidly due to faulty cell development in blood vessels. These malformations can range from minor to severe and may affect a person's daily functioning. Current treatments, such as medications like rapamycin, have side effects and may not completely eliminate the malformations. Researchers Kathleen Cullion, Daniel Kohane, and postdoctoral fellow Weimin Tang developed a novel approach using drug-loaded nanoparticles to target venous malformations directly.
These nanoparticles, made from a specialized form of rapamycin, were injected into mouse models of venous malformations. After 20 days, the treatment reduced the size of the malformations by 70% after a single injection, demonstrating their potential as a more effective and targeted treatment option.
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