In Silico Targeting of Calpain-5 in Autosomal Dominant Neovascular Inflammatory Vitreoretinopathy (ADNIV) with Peptides and Natural Products
Autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV) is a rare retinal disease caused by gain-of-function mutations in the non-classical calcium-activated cysteine protease calpain-5 (CAPN5). These mutations lower the calcium threshold for catalytic-triad alignment with downstream effects including excessive proteolysis and retinal degeneration, making CAPN5 a therapeutic target.…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
