Renewed Importance of CEX in Monoclonal-Antibody Purification
Advanced chromatography resins and data-driven strategies are redefining monoclonal-antibody purification in modern biopharmaceutical manufacturing. The post Renewed Importance of CEX in Monoclonal-Antibody Purification appeared first on GEN - Genetic Engineering and Biotechnology News .
The article highlights the renewed significance of cation exchange (CEX) chromatography in the purification of monoclonal antibodies (mAbs) in the biopharmaceutical industry. As upstream systems generate higher titers of antibodies, downstream purification must evolve to meet the increasing complexity and impurity burden of the product streams.
CEX chromatography is particularly effective in separating mAbs from impurities due to the high isoelectric points of antibodies, while impurities often have lower pIs. The article emphasizes that traditional purification strategies are reaching their limits with more complex mAb formats, such as bispecific antibodies and antibody-drug conjugates, which require more precise downstream polishing to achieve the desired product quality.
Brief written by urgent.news from GEN Biotechnology's own syndicated text. Machine-written — read the original for the full account.
We haven't written up this one. GEN Biotechnology has the full story — the link below goes straight to it.
