Genetic Findings Provide Insights Into Leading Cause of Back Pain
Research scientists previously discovered that a gene connected to a protein called collagen IX, which helps hold the disc's structural fibers together, has been repeatedly linked to early-onset disc problems. The post Genetic Findings Provide Insights Into Leading Cause of Back Pain appeared first on GEN - Genetic Engineering and Biotechnology News .
A recent study published in Communications Biology reveals new insights into the leading cause of back pain, intervertebral disc degeneration (IVDD), by examining the role of gene activity in spinal disc health. Researchers from the Universities of Edinburgh and Bristol conducted experiments on zebrafish with a genetic mutation affecting the collagen IX gene, which is crucial for maintaining the spine's structural integrity.
As the fish aged, their spines displayed characteristics similar to human disc degeneration, including hardening of tissues and fusion of bones. The study uncovered disruptions in fat metabolism, phosphate handling, and vitamin A signaling pathways, which led to mineral buildup in the spine, similar to the formation of unwanted bone tissue.
Researchers also found that these disruptions occurred well before any mineral accumulation began. The team tested several approaches to mitigate the damage, including the use of bisphosphonate, a drug already used to treat osteoporosis, and reducing fat metabolism in the fish. These methods successfully reduced spinal fusions and mineral buildup.
Dr. Erika Kague, the lead researcher from the University of Edinburgh, believes the findings could lead to new drug targets for treating back pain, providing hope for the 9.5 million people in the U.K. living with chronic back pain.
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