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Does FLAIR super-resolution erase or hallucinate small white-matter lesions?

White matter hyperintensities (WMH), bright regions on Fluid-attenuated Inversion Recovery (FLAIR) scans are associated with cerebrovascular pathology and neurodegeneration. FLAIR is usually acquired with thick slices in clinical settings, giving it poor through-plane resolution. Super-resolution (SR) is a widely used method for recovering an isotropic volume from an anisotropic scan. Yet whether…

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