Transcriptomic profiling of HBV transgenic mouse livers reveals ZBP1-associated necroptotic signaling

This study utilized an HBV transgenic mouse model to analyze the transcriptomic response in liver cells following persistent HBV expression. The researchers identified 815 candidate differentially expressed genes, with many of these genes involved in immune-related, metabolic, and viral infection-related pathways. The findings revealed increased levels of ZBP1, p-RIPK3, and p-MLKL in HBV-Tg livers, suggesting an association between HBV-Tg liver status and elevated necroptotic signaling markers.

However, further functional studies are needed to determine the cell specificity, causal direction, and contribution of this signaling axis to liver injury. The study highlights the importance of understanding the in vivo hepatic transcriptional response to HBV expression, as well as the potential role of necroptotic signaling in HBV-related liver injury.

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