Trajectory Uncertainty Framework (TUF): A Modular Framework for Identifying Transitional and Branch-Point Cell States in Single-Cell Trajectory Analysis
Single-cell trajectory inference methods assign pseudotime coordinates but provide limited information on assignment uncertainty, especially at transitional states and branch points. We introduce the Trajectory Uncertainty Framework (TUF), a modular, downstream approach that defines a 2D uncertainty coordinate system for single-cell data. TUF decomposes local uncertainty into the Temporal Entropy…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
