Study uses living human brain tissue to map how electric stimulation affects neurons and genetic activity
Neurons that once encoded a person's memories are now helping researchers identify genetic targets that may one day help preserve memory and slow cognitive decline in others.
Researchers have used living human brain tissue to study how deep brain stimulation affects neurons and genetic activity. Published in Nature, the study by UCLA Health and University of Texas Southwestern Medical Center is the first to mimic deep brain stimulation on living human-derived brain tissue outside the body. The researchers found that electrical stimulation increased neuronal synchrony, a pattern believed to aid memory formation.
Additionally, they discovered that both neurons and non-neuronal cells like astrocytes activated distinct genetic programs in response to stimulation. This work reveals new molecular targets for future therapies aimed at preserving memory and slowing cognitive decline. The study's senior author, Genevieve Konopka, emphasized the significance of using donated living human brain tissue to uncover the genetic and cellular mechanisms underlying human brain plasticity.
However, further research is needed to fully understand the long-term effects of stimulation, the impact on neighboring cells, and the therapy's effects on deeper brain regions.
Written by urgent.news from Medical Xpress's reporting — not their text. Machine-written — may contain errors; check the original before relying on it.
