Cancer Dependency Map now includes next-generation 3D cancer models
For nearly a decade, the Cancer Dependency Map, or DepMap, at the Broad Institute has helped scientists uncover new cancer dependencies—the genetic changes some cancers need to thrive that can potentially be targeted by new cancer drugs.
Nearly a decade after its inception, the Cancer Dependency Map (DepMap) at the Broad Institute has evolved to incorporate nearly 150 next-generation 3D cancer models across 10 cancer types. By integrating these 3D models with the existing dataset of over a thousand 2D models, DepMap now offers a more comprehensive resource, potentially uncovering additional drug targets and disease-driving mechanisms.
A study published in Nature reveals new dependencies in the 3D models that were not observed in 2D models, including those specific to certain brain and gastrointestinal cancers. These findings provide valuable insights for researchers studying next-generation 3D cancer models and help them choose between traditional and next-generation models for their work.
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