Lower cardiac output predicts faster brain loss in carriers of Alzheimer's disease risk gene
In a longitudinal study conducted at Vanderbilt Health, including investigators from the Vanderbilt Memory and Alzheimer's Center (VMAC), researchers found that lower cardiac output is associated with accelerated cerebral atrophy among older adults who carry the APOE-e4 allele, a genetic risk factor for Alzheimer's disease.
A recent longitudinal study conducted at Vanderbilt Health has found that lower cardiac output in older adults is linked to faster brain loss, particularly in those who carry the APOE-e4 allele, a genetic risk factor for Alzheimer's disease. The research, published in Alzheimer's & Dementia, tracked 756 participants over an 11-year period using data from the Vanderbilt Memory and Aging Project.
Among those with the APOE-e4 gene, reduced cardiac function at the start of the study was associated with smaller overall brain volumes and more rapid temporal lobe atrophy, an area linked to Alzheimer's. Lead author Dr. Elizabeth Moore emphasized that even subtle reductions in cardiac function could have significant implications for brain health, especially in individuals with a genetic predisposition to Alzheimer's.
The study underscores the importance of a precision medicine approach, considering genetic information to tailor prevention and screening efforts for Alzheimer's disease.
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