Explainable HGT-based framework for predicting human dark kinase protein-pathway associations by leveraging BERT-based embeddings and WGAN-GP
Discovery of pathway associations and druggability can leverage underutililized dark kinase genes for treating complex diseases (proven for cancer and neurodegeneration), boosted with computational methods. Herein, we employ BERT-based embeddings of proteins and pathways (refined via two-stage transformer and heterogeneous graph transformer) and protein-protein and protein-pathway associations-…
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