Clusterin regulates microglial inflammation and cognitive function independent of amyloid pathology in Alzheimer's disease
Clusterin (CLU) is a major genetic risk factor for late-onset Alzheimer's disease (AD), yet the mechanism underlying this risk remains unclear. This study investigated the role of CLU in regulating microglial inflammation, amyloid pathology, and cognitive function in CLU-deficient and AD models. CLU synthesis and secretion in microglia were highly dynamic, with minimal expression at rest but…
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