A legacy written in DNA
Bequeathing his body to the PEACE study, Edward Speed is one of many helping to reveal the hidden impact of cancer treatment both before and after death – including how DNA in healthy tissue might change. The post A legacy written in DNA appeared first on Cancer Research UK - Cancer News .
Edward Speed, a member of the board that helped raise £100 million for the Francis Crick Institute, has left a lasting legacy through his decision to donate his body to the PEACE study. This Cancer Research UK-funded programme collects tissue samples from terminally ill individuals, both before and after their death, providing researchers with a unique opportunity to study the impact of cancer and its treatments on the body.
Recent analysis of data from 22 participants in the PEACE study has uncovered unexpected 'mutational fingerprints' in healthy organs of people with advanced cancer, offering new insights into how cancer and its treatments affect various parts of the body. The findings reveal genetic changes associated with immunotherapy, a treatment not previously thought to directly damage DNA, which may be explained by the selective pressure cancer treatments place on cells.
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