UV photodamage pathways and the evolutionary selection of thymine over uracil in early genetic systems
Proceedings of the National Academy of Sciences, Volume 123, Issue 33, August 2026. SignificanceWhy DNA uses thymine instead of uracil remains photochemically unresolved, since thymine is more susceptible to ultraviolet (UV) damage. Resolving this paradox is central to understanding how life emerged and persisted under intense early ...
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