Non-invasive tests for the evaluation of liver fibrosis in MASLD
Nature Medicine, Published online: 03 August 2026; doi:10.1038/s41591-026-04560-x In the LITMUS imaging study, we assessed non-invasive alternatives to liver biopsy histopathology in metabolic dysfunction-associated steatotic liver disease (MASLD). Elastography and elastography-based composite scores had sufficient diagnostic accuracy to replace liver biopsy histopathology in evaluating advanced…
The LITMUS imaging study evaluated non-invasive alternatives to liver biopsy in assessing fibrosis and cirrhosis in metabolic dysfunction-associated steatotic liver disease (MASLD). Elastography and elastography-based composite scores proved accurate enough to replace liver biopsy for diagnosing advanced fibrosis and cirrhosis. However, no markers were found to be as effective in diagnosing metabolic dysfunction-associated steatohepatitis (MASH). The study was published in Nature Medicine and is available via subscription.
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