Metabolic dysfunction-associated steatotic liver disease linked to higher odds of eosinophilic esophagitis
Metabolic dysfunction-associated steatotic liver disease (MASLD) is significantly associated with eosinophilic esophagitis (EoE), according to a study published online July 22 in the Journal of Gastroenterology and Hepatology.
A study published in the Journal of Gastroenterology and Hepatology on July 22, 2026, has found a significant association between metabolic dysfunction-associated steatotic liver disease (MASLD) and eosinophilic esophagitis (EoE) in adults. Researchers from Case Western Reserve University in Cleveland, led by Dr. Rishi Chowdhary, examined data from the TriNetX U.S. Collaborative Network database to identify adult patients with and without MASLD.
After propensity matching, the analysis included 266,980 patients aged 18 to 44, 385,138 patients aged 45 to 64, and 150,640 patients aged 65 and older. The study revealed that the odds of EoE were substantially higher in patients with MASLD across all age groups: 2.905 for ages 18 to 44, 2.423 for ages 45 to 64, and 2.327 for those aged 65 and older.
Similarly, patients with MASLD also exhibited significantly higher odds of gastroesophageal reflux disease (GERD), nonerosive reflux disease, erosive esophagitis, and Barrett's esophagus. As the prevalence of MASLD continues to rise globally, the authors emphasize the need for increased vigilance for esophageal complications in this population.
Future prospective studies are required to establish causal mechanisms and determine whether targeted metabolic interventions can mitigate the risk of esophageal disease in MASLD patients.
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