Retraction Note: Human HDAC6 senses valine abundancy to regulate DNA damage

Following the publication of a 2024 Nature article, concerns emerged surrounding the accuracy of the numerical data presented in figures 4c, f, 5c, f, 6c, m, 3j, 5o, and 10b, d, h, n, and 9i. These figures detail the quantification of γH2AX-positive cells under various experimental conditions, as well as analyses of 5hmC, 5fC dot blots, and nucleotide-protein interactions.

The discrepancies raised include similarities within and between figure panels, prompting the editors to reevaluate the research's validity. Upon further investigation and correspondence with the authors from Tongji University, the editors concluded that the explanation provided for the observed data similarities was insufficient.

Additionally, they expressed doubts about the thoroughness of the independent confirmation process conducted by the institution. Consequently, the editors rescinded their confidence in the article's findings, leading to its retraction. While some authors, such as Ping Wang, Yihua Chen, and Jian Yuan, concur with the retraction, others, including Jiali Jin, Tong Meng, Yuanyuan Yu, and Shuheng Wu, maintain their support for the original publication.

The decision highlights the importance of robust data verification and the potential consequences of inadequately addressed data inconsistencies in scientific research.