PLK1-mediated phosphorylation of PHGDH reprograms serine metabolism in advanced prostate cancer
Proceedings of the National Academy of Sciences, Volume 123, Issue 31, August 2026. SignificanceThis study establishes a previously unrecognized link between PLK1, a key cell cycle regulator, and serine metabolism in prostate cancer. We demonstrate that PLK1 phosphorylates PHGDH, driving metabolic reprogramming by suppressing de novo ...
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