MORC2 controls HIF-1α stability via an HDAC4-dependent mechanism to regulate erythropoiesis
Proceedings of the National Academy of Sciences, Volume 123, Issue 31, August 2026. SignificanceThis study identifies MORC2 as a crucial negative regulator of HIF-α. We define a mechanism in which MORC2 competes with HDAC4 for HIF-1α binding to govern its acetylation and stability. This competitive binding is essential for normal ...
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