Methionine oxidation alters both helical assembly and disordered contacts in human TDP-43 C-terminal domain phase separation
Proceedings of the National Academy of Sciences, Volume 123, Issue 31, August 2026. SignificanceHow chemically specific modifications tune interaction networks within disordered proteins and regulate condensate stability remains poorly understood. By integrating residue-resolved NMR spectroscopy with all-atom molecular simulations, we ...
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