Location-dependent proteomics of the aorta reveal an atherosclerotic disease gradient shaped by hemodynamics
Background and aims: Atherosclerotic plaques form preferentially at vascular sites exposed to disturbed blood flow, yet the protein changes underlying this site-specific plaque development remain unclear. Mouse models are widely used to study atherosclerosis but yield only limited amounts of tissue, previously restricting proteomic studies. However, recent advances in mass spectrometry now enable…
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