Simulation-guided non-thermal low-intensity ultrasound reprograms the tumor immune microenvironment and engages systemic antitumor immunity in a syngeneic orthotopic mouse model of breast cancer
Introduction: Therapeutic ultrasound has been extensively studied in ablative and sonodynamic contexts, leaving the intrinsic bioactivity of continuous non-thermal low-intensity ultrasound (LIU) largely uncharacterized. Objectives: To characterize the tumor biological and immunomodulatory effects of non-thermal continuous LIU in complementary in vitro and in vivo breast cancer models, underpinned…
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