Fpk1 regulates Cdr1 expression and ergosterol homeostasis in Nakaseomyces glabratus (Candida glabrata) during azole exposure.
Azoles remain the most common antifungal therapy worldwide. However, Nakaseomyces glabratus (previously named Candida glabrata) has a high intrinsic tolerance against azole drugs. The organism can also accrue additional chromosomal mutations to elevate its resistant level during treatment. These genetic alterations often result in overexpression of the ABC transmembrane transporter Cdr1, which…
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