AI4Loop: an Artificial Intelligence Framework Reveals Increased 3D Chromatin Interactions and Therapeutic Vulnerabilities across 12,000 Cancer Samples
Three-dimensional chromatin interactions shape gene regulation, but their large-scale analysis remains limited by the cost and complexity of experimental assays. Here we present AI4Loop, a deep learning framework that infers genome-wide gene-centered chromatin interaction networks directly from RNA-seq data. Across multiple cell types, AI4Loop recovered interaction patterns consistent with…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
