Structural and functional basis of the non-canonical human Dicer-tRNA complex
Human Dicer (hDicer) is a key enzyme in the RNA interference (RNAi) pathway that generates ~21-22 nt micro-RNA (miRNAs) and small interfering RNAs (siRNAs). We have previously shown that hDicer also generates tRNA-derived small RNAs (tsRNAs), which mediate nuclear gene silencing and regulate hundreds of disease-associated genes. As powerful and evolutionarily conserved cellular regulators, tsRNAs…
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