Post-transcriptional glucocorticoid receptor signalling synchronises circadian rhythms
Circadian rhythms are driven by daily cellular clocks throughout the body that maintain optimal health. Glucocorticoid (GC) hormones are vital for synchronising cellular clocks, aligning them with external day/night cycles, but the mechanism was unresolved. We use a glucocorticoid receptor (GR) KO/rescue approach to show that residue E755 and the N-terminal intrinsically disordered region are…
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