Phosphorylation and pocket-binding ligands rewire the coupled networks in multidomain protein condensate
Biomolecular condensates formed by multidomain proteins are increasingly linked to disease and are emerging targets for chemical modulation. Yet most molecular models emphasize intrinsically disordered regions (IDRs), whereas many available ligands bind folded-domain pockets. How IDR modifications and folded-domain ligands are integrated to control condensate organization remains unclear. Here,…
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