Phage Display-Derived Cyclic Peptides as Ligand-Specific Modulators for β2-Integrin Receptors
The leukocyte-specific {beta}2-integrin receptor family exerts a wide range of functions: {beta}2- integrins are involved in leukocyte trafficking, where they mediate cell adhesion during inflammatory responses via binding to ICAM-1, ICAM-2, or JAM-C. Furthermore, they are essential for the recognition and phagocytosis of pathogens opsonized by complement. Accordingly, the {beta}2-integrin family…
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