Osteocyte State Transitions Modulate Bone Remodeling During Early Skeletal Aging
Osteocytes are long-lived cells that play a central role in bone homeostasis, yet age-related changes in their functional states remain poorly understood, particularly because skeletal aging involves multiple processes beyond cellular senescence. We generated an osteocyte-specific MepeCre mouse line and combined osteocyte ablation in young and middle-aged mice with skeletal phenotyping,…
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