Oligomannose Fc Glycans Reprogram the Energetic and Conformational Basis of CD16a Recognition
IgG1 Fc recognition by Fc{gamma}RIIIa/CD16a is a central determinant of antibody-dependent cellular cytotoxicity and is strongly regulated by Fc N297 glycosylation. While afucosylation and galactosylation have been extensively studied, the structural basis by which oligomannosidic Fc glycans modulate CD16a binding remains less clear, despite their prevalence in therapeutic antibodies and…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
