KDM6A Loss Confers an Invasive Phenotype in Osteosarcoma by Activating Cytoplasmic YAP-Dependent β-catenin Stabilisation
Osteosarcoma (OS) is the most common primary malignant bone tumour and is characterised by aggressive growth, early metastasis, and a very stagnant clinical outcome. Although epigenetic dysregulation has been implicated in OS progression, the mechanisms linking epigenetic alterations to metastatic signalling remain unclear. Here, we identified the lysine-protein demethylase 6A (KDM6A/UTX) as a…
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