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GESTURE: Unsupervised Genotype-specific Behavioral Phenotyping in Rodents via Graph-based Representation Learning

Objective quantification of complex animal behavior is fundamental to neuroscience and pharmacology, yet extracting biologically meaningful insights from high-dimensional pose data remains challenging. This is especially true for subtle phenotypic differences caused by genetic mutations, which frequently evade conventional evaluation metrics. Here, we introduce GESTURE, an unsupervised,…

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