FuncSeek: Multi-PLM contrastive learning for protein functional similarity search
Below 30% pairwise sequence identity, alignment-based methods struggle to reliably distinguish true homologs from chance (Rost 1999), and enzyme function prediction degrades accordingly: on proteins in this regime, even advanced methods (CLEAN) achieves only 55.1% accuracy at full EC specificity on the CARE benchmark (Yang et al. 2024). To this end Protein Language Models (PLMs) have gained favor…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
