CRISPR-Mediated Targeting of BRAF Oncogenes in Pediatric Low-Grade Glioma
Pediatric low-grade glioma (pLGG) is the most common brain tumor of childhood, accounting for 30-50% of all pediatric central nervous system malignancies. The disease is almost universally driven by activating mutations in the BRAF serine/threonine kinase: a chromosomal tandem duplication generating the KIAA1549-BRAF oncofusion in approximately 70% of cases, or the BRAF V600E gain-of-function…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
